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Sirtuin 5 (SIRT5), which is overexpressed in lung cancer, decrease the succinylation of GLS to regulate ammonia production and ammonia-induced autophagy [67]

NLRP3 inflammasomes encompass a central nucleotide-binding and oligomerisation (NACHT) domain, which contributes to self-oligomerisation and has ATPase activity

doi: 10.7554/eLife.61980 147 CosgroveJMaraisAHartmannFJBergthalerAZanoniICorradoMet al

Owing to its antioxidant properties, it has been suggested that GPx1 may inhibit cancer initiation by limiting ROS-mediated DNA damage

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid beta production and BACE1 in a mouse model of Alzheimers disease: implications for neuroprotection and lifespan extension