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Although some groups performed experiments on small samples [144, 145], these are not statistically solid because numerical samples of about 50 patients are not sufficient for these methods

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This work was supported by the Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Suematsu Gas Biology Project (to M.S.)

Meanwhile, DAO is localized in peroxisomes, while 3-MST mainly exists in mitochondria

The tradeoff is increased cost and longer downtime compared to traditional microneedling