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Melatonin expresses anti-inflammatory and antioxidant properties, and regulates different biological functions such as sleep, circadian rhythm, immunity, reproduction and blood pressure control

Results We used the GSH/GSSG-Glo Assay to monitor GSH and GSSG levels and observe the oxidative stress in adherent HEK-293 cells and suspension K-562 cells dosed with menadione (Figures 3 and 4)

Overall, MSM alleviates pathogen- and stress-induced physiological disorders in poultry primarily by modulating inflammatory signaling and enhancing antioxidant defenses, although its efficacy may vary depending on the disease-specific contexts

The response to ER stress plays a pivotal role in MTX-induced apoptosis, where MTX primarily triggers ER stress via the PERK/CHOP pathway (Song et al., 2021)