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Its local pharmacological characteristics provide a new idea for the treatment of obesity.AOD 9604, as an anti-obesity polypeptide targeting subcutaneous adipose tissue, achieves the effect of local fat reduction by activating lipolysis and inhibiting fat production

When cells contain fat stores, such as differentiated 3T3-L1 cells (145) as well as HeLa cells grown in oleic acidrich medium (115), desnutrin/ATGL is found both in the cytoplasm and tightly associated with the lipid droplet (115, 130, 145)