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Thus muscle derived FGF21 in Cpt1b m/ mice could have anti-inflammatory action locally in the presence of intracellular toxic lipids, and on adipose or possibly other tissues by circulation contributing to the improvement in inflammatory status at the face of constantly elevated systemic lipids

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doi: 10.1016/j.atmosenv.2005.10.064 126 NagasawaK.SetoguchiH.SakaguchiS

Similar content being viewed by others Introduction As copper (Cu) is a trace element in the human body, its intracellular concentration is maintained at a very low level by evolutionarily conserved homeostatic mechanisms that prevent the accumulation of free copper within the cells

This activation leads to downstream suppression of inflammatory mediators while promoting anti-inflammatory cytokine release