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Defyne is the firmer of the two, and works best for deeper placements

Apoptosis induction is the most consistently reported, involving caspase3/7 activation, Bcl2 inhibition, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, reactive oxygen species (ROS) generation, and lysosomal membrane permeabilization [20, 22, 26, 43, 68] (Figure 2)

Identification of a New High-Affinity Binding Protein for Neurotoxic Phospholipases A2

Liposomes as a delivery vehicle, adsorb to the stratum corneums surface and release PCs directly on the skin via adsorption or they can fuse with the SCs lipid matrix facilitating the diffusion of PCs within the skin [316]

doi: 10.1016/j.cellsig.2012.01.008