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To further test the role of GCL in modulating glutathione and glutamate, we utilized sulforaphane, which increases GCL expression through activation of the Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) pathway (22)

Aging, antagonistic pleiotropy and fibrotic disease

Mutations in the GCDH gene result in the organic acidemia called glutaric acidemia type 1

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While many menstrual changes during tirzepatide treatment represent benign adaptive responses to weight loss, certain patterns warrant prompt medical evaluation to exclude other underlying conditions