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Specifically, it was reported that among 66 patients with relapsing/refractory AMLs bearing the IDH1 mutation, an overall response rate of 36% was observed, along with a complete remission rate of 18%

[DOI] [PubMed] [Google Scholar] 510.Jiang, D

Interrupting the blood supply causes several pathophysiological alterations that lead to irreversible neural disruption, such as the production of oxygen free radicals and cerebral edema, reactive oxygen species, neuroinflammation, blood-brain barrier (BBB) destruction, and local inflammatory cell infiltration (Wang et al., 2021)

CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Li Q, Zhao Z, Zhou D, Chen Y, Hong W, Cao L, et al