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This result strongly suggests that hGSTA4-4 and hGST5.8 are specifically adapted by human cells for the purpose of detoxifying 4-HNE to abrogate the downstream effects which such a buildup would cause

doi: 10.3390/biomedicines11051340

[DOI] [PubMed] [Google Scholar] 73.Janson B.J., Alward W.L., Kwon Y.H., Bettis D.I., Fingert J.H., Provencher L.M., Goins K.M., Wagoner M.D., Greiner M.A

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