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62 Additionally, GSTs contribute to the regulation of cellular redox balance by modulating reactive oxygen species and reactive nitrogen species levels through the conjugation of GSH to oxidized molecules

Abstract Mitochondria are the powerhouses of the cell and are involved in essential functions of the cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species production & scavenging, regulation of apoptotic cell death and activation of the caspase family of proteases

Akin to adaptive SE-transcriptional programs-associated Ven resistance in solid tumors (Rusan et al., 2018), CDK7 inhibition can restore Ven-sensitivity in Ven-DTEP cells by repressing SE-driven expression of pro-survival genes and further reducing the expression of BCL2

Notably, resveratrol influences the metabolic reprogramming of macrophages by modulating the AMPK/mTOR signaling pathway [227]
192 One potential mechanism for this antioxidant effect is the ability of apoM to bind and sequester oxidized phospholipids 193
