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Within one year after CAR-T cell therapy, progressive disease can be observed in roughly 50% of B-cell leukemia and LBCL, 2030% of FL, 40% of mantle cell lymphoma, and 2040% of MM patients [2,3,4,5,6,7,8,9,10,11, 13, 15]

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Nat Rev Immunol (2016) 16:55365.10.1038/nri.2016.70 6 BuckMDSowellRTKaechSMPearceEL

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According to the European Medicines Agency assessment report on HPL, lyophilized 65% ethanol extracts (5:1, 100 mg of extracts were equivalent to 500 mg of HPL) were standardized to 0.3% hypericin and contained 1.09% rutin, 0.65% hyperoside, 0.45% isoquercitin, 0.04% quercitrin, and 0.07% quercetin (the HPL flavonoid content determination is described in Supplementary method I, Supplementary Figure S1, and Supplementary Tables S1, S2)

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Expert Opin Ther Targets (2012) 16(9):889901

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2026 Jun 11;7(6):e70809

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