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10.15252/embr.201949863 201 XuF.SuyamaR.InadaT.KawaguchiS.KaiT

The major pathogenetic mechanism of GD is the stimulation of the thyroid stimulating hormone receptor (TSH-R) by autoantibodies that bind to it and promote thyrocyte proliferation and activity, resulting in thyroid hyperfunction (13)

Although these findings provide significant mechanistic insight, they primarily originated from animal or in vitro studies, and their translational relevance to long-term human health remains uncertain

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Nat Immunol 8: 864872 [DOI] [PubMed] [Google Scholar] Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M 2003