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Description
Some people may experience dark under-eye circles due to factors like poor sleep, stress, or nutritional deficiencies

[DOI] [PMC free article] [PubMed] [Google Scholar] 712

This suggests an important role for leucine in mitochondrial adaptation to nutrient changes

obs works similar to E max and 2 is analogous to half-maximal effective concentration (EC50) in traditional single drug pharmacology

Individual results vary significantly
