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High creatine synthesis demand Endogenous creatine synthesis consumes a large fraction of SAM-derived methyl groups and generates SAH

CIPN was evaluated at the enrollment visit and repeated every 3 weeks for up to 3 months

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Contact dermatitis N-acetylcysteine is known to be protective in irritant contact dermatitis and contact hypersensitivity reactions in mouse models which is attributed to its ability to inhibit TNF-alpha by reducing nuclear factor-B