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Because of the incomplete clinical evidence on their effectiveness, safety, and social consequences in the case of long-term use, especially with synthetic variants of these drugs, they cannot be recommended to healthy individuals who do not suffer from any cognitive dysfunction

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Early reports suggest its well-tolerated, but long-term safety is still being evaluated

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OIG Audit Report A-09-23-03014 (May 27, 2025) found that 22 of 24 reviewed intravitreal injection claims with modifier 25 had documentation that didnt support the modifier