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doi:10.4196/kjpp.2019.23.1.29 54

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33 suggested that dietary flavanols might not only protect Caco-2 cells against an induced oxidative stress and subsequent cellular death by directly scavenging free radicals, but also by preventing caspase-3 activation and by activating cellular the Caco-2 cells own antioxidant defences, e.g

These cells are pivotal in metabolism, tissue homeostasis, morphogenesis, and tissue repair and regeneration (108)

However, in a subsequent phase II trial (IMAGINE), PBT2 failed to demonstrate significant improvements in cognitive function or reductions in A burden compared with placebo after 12 months of treatment