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The transcription factors XBP-1, ATF-4 and ATF-6 activate ERAD (Endoplasmic Reticulum Associated Degradation) components, genes regulating lipid synthesis, and upregulate ER resident chaperones, such as the Ig-binding protein BiP ortholog HSP-4

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The invasion assay was done by the same procedure with transwell inserts pre-coated with matrigel (Corning BioCoat, CLS354480, USA), and 5 10 4 tumor cells were added to the upper chamber

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