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Additionally, stroke was addressed in five publications, whereas Raynauds syndrome (RS) and cognitive disorder (CD) each had three dedicated studies

Neither study included a comparison group that would allow careful evaluation of the safety and efficacy of treating this population.Hematological adverse events, including anemia, neutropenia, or thrombocytopenia are more common in persons with than in those without cirrhosis, and especially in those with clinically decompensated disease158-160
