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Description
Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line
Data Availability Statement This narrative review is based on a comprehensive analysis of previously published studies and does not involve original data collection.
As discussed later in this review, this mediator is the transcription factor peroxisome proliferator-activated receptor coactivator 1 (PGC-1 ), and its role in simultaneously inducing bioenergetic and antioxidant adaptations has been demonstrated in several experimental models of mtROS production, including treatments with paraquat and H 2 O 2
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In contrast, GH administration is not advised for anti-aging in healthy elderly due to increased adverse events (Liu, Bravata, Olkin et al., 2007)
