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To determine CNS penetrance, the levels of D and Q in CSF were measured using high-performance liquid chromatography with tandem mass spectrometry

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Exclusion criteria Articles fulfilling the following criteria were excluded from the present study: i) Randomized trials without a placebo or control group

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Cipriano, C., Tesei, S., Malavolta, M., Giacconi, R., Muti, E., Costarelli, L.,
