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Figure 1 3 Integrative acupuncture and drug therapies for diabetic nephropathy 3.1 Acupuncture in diabetes: A foundation for DN research Based on the theory of zangfu organs and meridians, acupuncture for diabetic nephropathy (DN) is guided by syndrome differentiation and follows the principle of tonifying the kidney and spleen, promoting blood circulation, and unblocking the collaterals, reflecting its holistic and multi-target regulatory effects (53)