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Research indicates that genetically modified mice that lack ADRB3 may be resistant to the action of hGH / Fragment 176-191, suggesting that this may indeed be the primary mechanism

The following databases were searched: Ovid MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Ovid Embase, Wiley Cochrane, EBSCO Cumulative Index to Nursing & Allied Health Literature (CINAHL), and Centre for Reviews and Dissemination/International Agency for Health Technology Assessment