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32 Enzymes play a significant role in maintaining a balance between antioxidants and free radicals by either generating or breaking down ROS
The cyclic lactam constraint between the Asp and Lys side chains preorganizes the conserved His-Phe-Arg-Trp (HFRW) message tetrapeptide of -MSH into the receptor-bound conformation, which is responsible for the dramatic potency increase relative to the linear native hormone
