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pH is a measurement of the concentration of hydrogen ions (H+) in solution
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Inadequate target design and preclinical models can lead to low translation rates in clinical trials
Toor, H
Because cuproptosis preferentially targets cells with high oxidative phosphorylation (OXPHOS) dependency, whereas glycolytic tumors remain relatively resistant, it exposes a distinct metabolic vulnerability in cancer and presents unique therapeutic opportunities 165,166
