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*Correspondence: Lai Fong Chan [email protected] This article was submitted to Mood Disorders, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

45,78,84 Leptin can also directly stimulate inflammation by promoting the M1 macrophage phenotype 120 and increasing pro-inflammatory cytokines such as IL-6, IL-1, and TNF-