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Mechanisms of action Anti-CD38 antibodies exert their therapeutic effects via direct effector mechanisms on MM cells (i.e., CD38 enzymatic inhibition, direct induction of apoptosis) and through Fc-dependent immune mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), complement-directed cytotoxicity (CDC), and antibody-directed cellular phagocytosis (ADCP) (Fig

To further explore whether AOD 9604s lipolytic interactions depend solely on enhanced receptor expression, investigations were also conducted using mice with genetically ablated lipolytic receptors in laboratory settings

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