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MSM (methylsulfonylmethane) is commonly in supplements for joint and muscle pain, although the evidence behind it has been limited

It increases the expression of superoxide dismutase (SOD) , the primary defense enzyme against superoxide free radicals

Mary Brunkow, Ph.D., from Providence-affiliated Institute for Systems Biology, was awarded the Nobel Prize in Physiology or Medicine

Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases

Muscle & Nerve, 2013