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Eur J Clin Pharmacol 1992;43:667-669

Alarmingly, recent epidemiological reports indicate that antimicrobial resistance is now considered one of the mainly death worldwide, surpassing several major infectious diseases 84

10.1016/j.bbi.2016.03.020

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IL-1 and TNF- stimulate chondrocytes and synovial cells to secrete MMP-1, MMP-3, and MMP-13, which degrade collagen and proteoglycans in the cartilage matrix, worsening cartilage damage (150, 151)
