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EVIDENCE OF INCREASED NITRIC OXIDE PRODUCTION AND RELATED MEDICAL SYMPTOMS IN ASD As mentioned earlier, once activated, microglia release large amounts of NO and superoxide as a cytotoxic attack mechanism (Colton and Gilbert, 1987)

Souto et al., 2005)

However, despite the inclusion of more than 60,000 children, the degree of uncertainty ranged from an odds ratio of 1.02 (clinically insignificant) to 1.66 (intolerable by any standard)