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Future studies should comprehensively characterize NPs, including their size, composition, shape, charge, application mode (immobilized in scaffolds or in a free form), and interactions with different tissue and cell types

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To examine the extent to which the phenotypes observed were specifically caused by lower GSH levels, we rescued GSH depletion in liver-specific Gclc KO mice with GSH mono ethyl ester (GSH-ee)

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Overall, preclinical data has shown that inhibiting the proinflammatory mediators could be exploited to reduce CDLBP by reducing neuronal inflammation