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In addition, NS extracts can decrease the bodys inflammatory and OS markers (159) as well as boost skeletal muscle glucose uptake and adenosine monophosphate-activated protein kinase (AMPK) activity (160)

In SV40-MES 13 cells, HMGB1 (high-mobility group box-1) has been recognized as a valuable factor of ferroptosis based on the Nrf2/HO-1 signaling pathway, proposing that HMGB1 is a new target for the treatment of DN [157]

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10.1016/j.taap.2014.05.010 Toxicol

Restoration of segregated, physiological neuronal connectivity by desynchronizing stimulation
