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Often associated with poor outcomes, acute crises were not observed for a five-year follow-up period following thiamin supplementation (300-400 mg/day) early diagnosis and immediate treatment with biotin and thiamin led to positive outcomes (118)

BioMed Research International 2015:648108

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Brain Glutathione and Oxidative Stress Brain concentrations of total and reduced GSH (tGSH and rGSH) were measured by ultraperformance liquid chromatography (Waters ACQUITY UPLC System) as reported by us previously [13,14,64]