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One more study indicates that upregulation of PTEN by MCR1 activation and inhibition of cyclooxygenase and prostaglandin E2 by melanotan II cause suppression of melanoma [10]

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Curr Biol 10:341344 [DOI] [PubMed] [Google Scholar] Tao YX, Johnson NB, Segaloff DL 2004 Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor
