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Detoxification and breaking down substances: Methylation is essential in the nervous system, in the production and breakdown of neurotransmitters, and in detoxifying some specific environmental toxicants such as arsenic

Thus, production and consumption of NADPH inside the cells should be coordinated to maintain NADPH homeostasis

10.1007/s00204-015-1579-5 10.1007/s00204-015-1579-5 [DOI] [PubMed] [Google Scholar] Vauzour D, Vafeiadou K, Rodriguez-Mateos A (2008) The neuroprotective potential of flavonoids: a multiplicity of effects

While this patient also uses topical diclofenac for her weight-bearing osteoarthritis, topical formulations have minimal systemic absorption and carry a significantly lower risk of gastrointestinal complications compared to oral NSAIDs