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Similar pathological changes to the liver are also observed in animal models of OXA or OXA-based chemotherapies
Subsequently, non-enzymatic self-oxidation occurs with molecular oxygen under the catalysis of the Fenton reaction, which is initiated by iron and H 2 O 2 to produce phospholipid peroxyl radicals (PLOO), which are generated by removing hydrogen from another PUFA to generate PLOOH ( Figure 1A )
Given the link between ROS damage and aging, several studies have examined how the sod mutations affect lifespan (see text box)
