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Description
Main conclusions: GHK-Cu acts via 6 main mechanisms (described above) The endogenous decrease with age is documented in various populations Topical applications in dermatology are the best validated Antimicrobial effect , GHK-Cu also has a mild antibacterial profile The safety profile is excellent, no toxic doses were reached in animal studies Why it matters: This review became a reference source for the dermatological and cosmetic research community
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IGF-1 produced in liver exerts mainly endocrine activity while IGF-1 synthetised by other tissues acts in a para- and/or autocrine way

10.1038/s41417-018-0031-4 122 ZhanF

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