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Description
Impairment of ubiquitinproteasome (UPS) and autophagy systems affects protein degradation in HD animal models and human tissues (Ravikumar et al
doi: 10.4049/jimmunol.0800854 123 JunejaVRMcGuireKAMangusoRTLaFleurMWCollinsNHainingWNet al
1999b;31:S121127
88,89,90,91 They are also known as occluding junctions or zonulae occludes which can restrict the cross of hydrophilic molecules and macromolecules
Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS
