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M2 macrophages primarily rely on enhanced fatty acid oxidation (FAO), an intact and active tricarboxylic acid (TCA) cycle, and upregulated glutamine metabolism to maintain their oxidative metabolic homeostasis and immunoregulatory functions

These deficiencies are often due to restrictive diets, food sensitivities, and gastrointestinal issues common in ASD

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Interestingly TBH also induces the expression of rat GCLC and the activity of the rat GCLC promoter even though the promoter lacks ARE (Yang et al., 2001