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The persistent activation of AHR by high-level IS can lead to the injury of podocytes and glomeruli (Tan et al., 2022)

Gastroenterology 137 , 14891497 (2009)
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Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury

This is why the scientific method is so rigorous
