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Glycocalyx degradation after cardiac arrest and resuscitation in rats induces vascular endothelial adhesion factor (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), iNOS, and COX-2 expression, exacerbating neuronal loss, glial activation, and brain edema
Other potential risks include allergic reactions, adverse effects, or IV infiltration
Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin
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Several peptides have shown clinical interest in managing chronic pain and inflammation
