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For these reasons, it is necessary to continue research to better know and understand the anticancer effects that melatonin can produce in patients, the effective dose, bioavailability, and the safety that it represents in the long term

doi: 10.1089/jmf.2017.4078

Some hit 34 months

& Ailshire, J

PRIMA1 and its more potent and methylated form (APR-246) act through targeting cysteine residues of p53 (Cys-124 and -277), leading to its refolding [693, 694]