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Review criteria Relevant studies published between January 1, 2000, and January 1, 2023, were identified from PubMed, EMBASE, Cochrane Library and the ClinicalTrials.gov registry, using the search terms Graves disease treatment, Graves disease therapy, Graves disease management, Graves disease pathogenesis, Graves orbitopathy, Graves ophthalmopathy, thyroid eye disease, thyroid-associated ophthalmopathy, thyroid ophthalmopathy, endocrine ophthalmopathy