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Under OS, excessive ROS also trigger release of inflammatory cytokines and transcription factors, establishing a positive feedback loop that perpetuates both OS and inflammation (38)
Alveolar defects have also been linked to reduced functional gas exchange (34)
Hansson J, Berhane K, Castro VM, Jungnelius U, Mannervik B, Ringborg U: Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid
doi: 10.1016/j.pathophys.2013.11.010 110 IbrahimA
Martelli S, Chow J
