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Consistent with these phenotypes, NINJ1 knockdown also inhibited other erastin-induced molecular features of ferroptosis, including membrane rupture (Fig
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In humans, ablation of NBP35 causes an impairment in the iron-regulatory protein IRP1, which in turn affects the levels of ferritin and increases the levels of transferrin uptake by a concomitant increase of transferrin receptor levels in the cell
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