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Through its support of serotonin synthesis, New Mood may help counteract stress and promote sleep, since serotonin plays an essential role in regulating the sleep-wake cycle

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Iron is a potential therapeutic target for IRI (Fig

Despite its theoretical appeal for treating insomnia ( Dopamine plays a crucial role in the transition from nonrapid eye movement (NREM) sleep to rapid eye movement (REM) sleep through a transient increase in the basolateral amygdala (BLA), acting on D2 dopamine receptors to initiate the NREM-to-REM shift

Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion