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Individual responses to glutathione supplementation may differ, and not everyone will experience the same effects or benefits

The demand for Se will increase after suffering environmental pressures, and supplementation is a necessary condition to meet the needs of fish growth (Nasir et al., 2015) and lack may have adverse effects on fish health, leading to tissue damage and physiological function weakening ( 4.1 Harmful effects of selenium excess Se is an essential micronutrient required for fish, which plays an important role in the antioxidant system and also affects the lipid metabolism, sugar metabolism and amino acid metabolism of aquatic animals (Yoboue et al., 2018

Apart from the common characteristic of anemia (decrease in red blood cells), anemia due to B12 deficiency presents a process of macrocytosis (increase in the size of red blood cells or erythrocytes) that manifests itself in the abnormal growth of blood cells (the aforementioned megaloblasts), all of which is the result of a failure of their nucleus to mature and an increase in cytoplasmic mass and maturation

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This hormone triggers an ovary to mature and release an egg