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Molecular understanding of hyperglycemia's adverse effects for diabetic complications

Unabsorbed L-carnitine is mostly degraded by microorganisms in the large intestine [3]

discussion 898 Moyle GJ, Sadler M

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The authors proposed that L-carnitine regulates the PTEN/Akt/mTOR signaling pathway, and enhances axonal plasticity while concurrently ameliorating oxidative stress and increasing oligodendrocyte myelination of axons and suggested that this attenuated cognitive impairment after chronic hypoperfusion [86] However, the increased CPT I and CPT II protein levels in L-carnitine treated rats may also have protected myelin after chronic hypoperfusion