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& Drancourt, M

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These findings were further corroborated by a preclinical work where Parkinson rats (induced by intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6- tetrahydropyridine, 20 mg/kg) recorded the highest depletion in dopamine concentration and highest lipid peroxidation activity following 60 days of oral intake of alcohol compared to cigarette inhalation or frequent mating (Ambhore et al., 2012

These findings indicate that multi-targeted drug combinations focused on mitochondrial energy metabolism may be a promising direction for migraine prophylaxis

Adding glycine to the formulation provides a direct molecular countermeasure, maintaining mTORC1 activity even during the energy deficit that drives fat loss