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The right panel describes strategies for managing peak-dose dyskinesias (involuntary movements during ON periods), which include reducing individual levodopa doses to lower the dopaminergic load or adding Amantadine to suppress the dyskinesia

Finally, NO produced by the endothelium affects skeletal muscle functions besides its canonical role in the regulation of vascular tone [77]

Metabolite damage and metabolite damage control in plants

Severe zinc deficiency is also associated with acrodermatitis enteropathica, a rare autosomal recessive genetic disorder (252)

So, during these conditions, most citrate is metabolized into the CPS, generating both cytoplasmic acetyl-CoA and NADPH for lipid synthesis