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Consistent with these findings, GSH-depleted mice showed significantly decreased weights of liver and epididymal (visceral) white adipose tissue (eWAT) (Figure 2, D and E), while weights of inguinal (subcutaneous) white adipose tissue (iWAT), brown adipose tissue (BAT), or skeletal muscle remained unchanged (Supplemental Figure 2, FH)

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[Google Scholar] 124.Whitley R.D

In obesity, dysfunctional adipose tissue induces pathological remodeling, including adipocyte hypertrophy, immune cell infiltration, the release of pro-inflammatory cytokines, impaired angiogenesis, and fibrosis, which collectively contributes to multiorgan inflammation, oxidative stress, insulin resistance, and metabolic dysfunction [33, 34]

Male and female mice were placed one by one in separate cages and mated